Anti-Aging

Taking around 70–80 supplements a day, he aims to extend his lifespan and stay mentally and physically sharp as long as possible. A major part of his supplement stack focuses on slowing aging. These selections are based on scientific research and reviewed regularly with medical professionals to match his long-term health goals.

• Resveratrol: 100 mg daily, taken with meals to support absorption. Known for activating sirtuins—proteins linked to longevity—and helping protect cells from age-related decline. Often mentioned as a cornerstone in his diet supplements.
• Phosphatidylcholine: 1,200 mg in the morning to help maintain cell membrane flexibility and improve memory. It also supports the production of acetylcholine, a key neurotransmitter for brain function.
• Ubiquinol: 200 mg daily, taken with a fatty meal for better uptake. Boosts cellular energy production and offers antioxidant protection. Considered one of his core three supplements for longevity.
• Alpha Lipoic Acid: 300 mg per day, split between morning and evening. This antioxidant helps combat advanced glycation end-products (AGEs), which are linked to aging and blood sugar issues.
• Carnosine: Used to reduce protein damage that can come with age. While the exact dosage isn’t specified, it plays a role in preserving muscle and supporting overall health as part of his anti-aging focus.
• N-Acetyl-Carnitine: 500 mg taken with breakfast to enhance mitochondrial function. Known for improving both mental and physical stamina, and often listed among his go-to daily supplements.

These anti-aging supplements form the foundation of his routine. Together, they reflect a science-first approach to health, combining high-potency ingredients with consistency and regular monitoring.

My goal is to stay healthy and vibrant until the singularity arrives.
Ray Kurzweil

Anti-Inflammatories

Inflammation is one of the body’s natural responses, but when it lingers, it can lead to bigger health problems over time. That’s why this section of the Ray Kurzweil supplements list focuses on reducing low-level, chronic inflammation.

He sees controlling inflammation as essential for long-term health and works closely with medical professionals to make sure his daily regimen stays effective and safe.

• Curcumin: 500 mg daily, typically taken in the evening. This turmeric-derived compound helps reduce inflammation throughout the body. He combines it with black pepper to boost absorption and make it more effective over time.
• EPA/DHA (Omega-3 Fish Oils): 2,000 mg per day, taken with food. These omega-3 fatty acids support heart function and help lower inflammation. He chooses high-strength formulas to ensure he gets enough, as part of his diet supplements for overall wellness.

This part of his supplement list shows a strong focus on prevention. By managing inflammation early, he aims to support long-term organ function, reduce wear and tear on the body, and stay ahead of age-related health issues.

Blood-Vessel Health

Ray Kurzweil prioritizes blood vessel health with specific supplements, recognizing their role in delivering oxygen and nutrients throughout the body.

This category in his Ray Kurzweil supplement list supports his aim to keep his circulatory system robust, a factor he ties to overall vitality and longevity. He adjusts dosages with medical input to ensure safety and effectiveness.

• Arginine: At 3,000 mg daily, this amino acid aids blood vessel health by promoting nitric oxide production. He takes it in divided doses, often with meals, to support vascular flexibility.
• Choline: Included in his 1,200 mg Phosphatidylcholine dose, this supports blood vessel function and liver health. He relies on its presence in his morning supplement stack for consistent benefits.
• TMG (Trimethylglycine): Taken at 500 mg daily, this lowers homocysteine levels to protect blood vessels. Ray uses it to reduce cardiovascular risk, taking it alongside his multivitamin for synergy.

These choices strengthen Ray’s blood vessels, supporting his energy levels and long-term health goals. His approach highlights the importance of circulation in his broader wellness plan.

Always speak with a healthcare professional before starting any new supplement, especially if it may affect your health or medication.

Brain Health

For someone who values long-term thinking, cognitive health is a high priority. Mental clarity, memory support, and stress control all play a role in his approach to staying sharp with age. This section of his supplement plan focuses on nutrients that support brain function throughout the day—and into the night.

• GABA: 500 mg taken in the evening to encourage calmness and reduce mental tension. This supplement helps support emotional balance and promotes restful sleep as part of his brain-focused routine.
• Alpha-GPC: Often used before tasks that require deep thinking. While the dose isn’t clearly shared, it’s valued for supporting acetylcholine levels, which are important for learning and memory.
• Melatonin: 1 mg taken about 30 minutes before bed. It helps regulate sleep, which he considers essential for memory and mental repair. A consistent sleep schedule is part of how he protects brain function over time.
• Quercetin: 500 mg taken in the morning with food. Known for its antioxidant activity, it helps reduce oxidative stress on the brain, which supports focus and overall mental health.
• Vinpocetine: Used occasionally to sharpen concentration during intense work sessions. The amount may vary, but it’s selected for its role in improving blood flow to the brain.

This group of supplements supports the foundation of his mental performance. From better sleep to sharper focus, they reflect a steady effort to protect and support brain health. These choices fit into a broader system of Ray Kurzweil health supplements aimed at staying sharp in the present and well into the future.

These supplements may not be suitable for everyone. Please consult your doctor or a licensed medical advisor before use.

Chelation Therapy

Ray Kurzweil uses chelation therapy to remove heavy metals from his body, a specialized part of his supplements routine. This approach addresses potential toxin buildup, which he believes can impact longevity. He undergoes these treatments weekly under medical supervision, ensuring they complement his oral supplement intake.

• DMPS: Used in weekly IV form to remove heavy metals like lead, the dose isn’t specified. Ray relies on this to detoxify his system, scheduling it as part of his health maintenance.
• EDTA: Also in IV form weekly, this binds heavy metals for excretion, with the dose not specified. Ray uses it to support overall detoxification, coordinating with his doctor for timing.

These therapies help Ray eliminate toxins, supporting his long-term health strategy. His inclusion of chelation reflects a comprehensive approach to wellness.

Before taking any supplement, it’s best to check with your physician to ensure it aligns with your personal health needs.

Digestion

Ray Kurzweil understands that even the most advanced supplements won’t be effective without proper digestion. That’s why gut health is a key part of his overall wellness strategy.

His digestion-focused stack supports nutrient absorption, reduces discomfort, and helps his body process the large number of supplements he takes daily. These choices are regularly reviewed with his doctors to match any changes in his diet or health.

• Acidophilus Bifidobacterium: Helps maintain a healthy gut microbiome, contributing to smoother digestion and immune function. Often taken with meals to support daily gut balance.
• Betaine HCL: Promotes proper stomach acid levels, which are essential for breaking down protein-rich foods. Commonly included with heavier meals to support digestion efficiency.
• Fish Protein: Serves as a clean and gentle protein source that’s easy on the stomach. Included in his morning regimen to support protein intake without digestive strain.
• Fructooligosaccharides: Acts as a prebiotic, feeding beneficial gut bacteria to encourage a stable digestive environment. Typically combined with probiotics for better impact.
• Gentian Root: Stimulates the release of digestive juices and enzymes, preparing the stomach for food. Often part of his pre-meal supplement stack.
• L-Glutamine: Supports the integrity of the gut lining and helps manage digestive stress. Taken on an empty stomach to assist with recovery and repair.
• N-Acetyl-D-Glucosamine: Contributes to gut lining repair, particularly when paired with glutamine. Plays a supportive role in maintaining a resilient digestive tract.
• Peppermint: Helps soothe the digestive system after eating and is frequently used for relief from bloating or minor discomfort.
• Pepsin: Assists with protein breakdown when combined with Betaine HCL. Enhances nutrient absorption by supporting enzyme activity during digestion.

This collection of gut-supporting supplements forms a key part of his overall health strategy. By focusing on digestion, he creates a solid base for the rest of his health supplements to deliver their full benefits.

Eye Health

Ray Kurzweil protects his vision with targeted eye health supplements, a thoughtful addition to his diet supplements list. He values maintaining clear eyesight as part of his overall health, adjusting these based on regular eye checkups. This category reflects his proactive stance on preventing age-related vision issues.

• Bilberry Extract: Taken at 100 mg daily, this supports eye health by protecting against retinal damage. he takes it with breakfast to maintain consistency.
• Lutein: At 10 mg daily, this supports eye function and reduces the risk of macular degeneration. Ray includes it to preserve vision, taking it in the morning.

These supplements help Ray safeguard his eyesight, a key aspect of his long-term health plan. His routine demonstrates care for every aspect of his well-being.

Individual health conditions vary. Be sure to consult a qualified healthcare provider before adding this to your routine.

Testosterone Boosters

Supporting hormone balance is another part of Ray Kurzweil’s supplement strategy, especially when it comes to maintaining energy, mood, and vitality. He uses a mix of natural compounds and prescribed treatments to help optimize testosterone levels, always in coordination with medical supervision.

• DHEA: Promotes natural testosterone production and supports libido and energy. Typically taken in the morning—25 mg for men, 15 mg for women—to align with daily hormonal patterns.
• Chrysin: Helps reduce the conversion of testosterone into estrogen. Added to his routine on occasion as part of a broader hormone support plan.
• Indole-3-Carbinol: Aids in hormone balance by improving estrogen metabolism. Often paired with meals for better absorption and steady effectiveness.
• Nettle: Contributes to testosterone support by limiting the binding of testosterone to proteins. Included to help maintain free testosterone levels.
• Testosterone (prescription): Managed under medical supervision to sustain optimal hormone function. Used as needed and adjusted based on regular testing.

These supplements reflect a focused effort to support hormonal wellness alongside other categories in the Ray Kurzweil supplements list. By keeping testosterone in check, he aims to maintain strength, motivation, and long-term vitality.

AGEs (Advanced Glycation End-products)

Ray Kurzweil takes targeted steps to reduce the effects of sugar-related damage, which he believes accelerates aging and chronic disease. His focus on AGEs stems from research linking these compounds to tissue breakdown and metabolic stress.

Supplements in this group are selected to help the body manage glycation and support long-term cellular function.

• Alpha Lipoic Acid: 300 mg daily, divided into two doses to maintain stable support throughout the day. Known for limiting glycation and assisting with blood sugar regulation.
• Carnosine: Included for its ability to block glycation of proteins, helping preserve muscle and tissue health. Dosage details aren’t shared, but it remains a consistent part of his routine.
• N-Acetyl-Carnitine: 500 mg taken with breakfast to support both energy and cellular defense. Also involved in counteracting the effects of AGEs at the mitochondrial level.

Homocysteine

Keeping homocysteine levels low is important for long-term heart and brain health. This section of the Ray Kurzweil health supplements list focuses on nutrients that regulate this marker, which is closely tied to cardiovascular risk. Each item is carefully chosen and monitored with blood tests to ensure proper balance.

• Vitamin B-6: 50 mg taken alongside his daily multivitamin. Supports enzyme activity that converts homocysteine into more useful amino acids.
• Folic Acid: 800 mcg added to support red blood cell production and cognitive function. Plays a direct role in breaking down homocysteine in the bloodstream.

With this targeted support, he reduces cardiovascular risk while maintaining overall metabolic balance. These supplements reflect the preventative mindset behind what supplements Ray Kurzweil takes daily.

Stress

Mental clarity and emotional balance are key parts of Ray Kurzweil’s health approach. To stay calm and focused under pressure, he uses specific supplements that support stress relief and relaxation. These choices are adjusted based on how he’s feeling and are designed to help him stay mentally resilient throughout the day.

• Beta-Sitosterol: Supports emotional balance by modulating cortisol and inflammatory responses. Often used to promote a calm state during periods of high workload.
• Green Tea Extract: Supplies 500 mg daily (with 250 mg EGCG) to ease stress while delivering antioxidants. Commonly part of his morning routine to encourage mental focus.
• L-Theanine: Provides 200 mg daily to ease anxiety and support a steady mood. Frequently combined with tea for a calming effect during high-pressure tasks.
• Phosphatidylserine: Delivers 100 mg in the evening to help wind down. Used to ease stress-related tension and support mental recovery at night.

These supplements help create a steady mental foundation that supports his daily performance. Stress management remains a steady focus within the Ray Kurzweil supplements routine, aligning with his larger goals for longevity and cognitive health.

Type 2 Diabetes

Managing blood sugar is an important part of Ray Kurzweil’s daily routine. Through a mix of supplements and prescribed medication, he works to keep glucose levels steady and reduce related risks. These additions are guided by medical testing and support his broader focus on long-term metabolic health.

• Chromium: Delivers 200 mcg daily to improve insulin sensitivity and promote healthy glucose levels. Typically taken with meals to support better blood sugar regulation.
• Gymnema Sylvestra: Assists with sugar control by reducing cravings and improving glucose metabolism. Usually taken before meals as part of his dietary strategy.
• Metformin (prescription): Used under medical supervision to manage blood sugar and support healthy aging. Also noted for its potential benefits beyond diabetes, including reduced cancer risk.

This selection supports more than just glucose control—it’s part of a broader effort to prevent complications and maintain metabolic efficiency. With consistent use and medical oversight, these supplements help reinforce his long-term health strategy.

This is not medical advice. Always get guidance from a healthcare expert before trying supplements with potential medical effects.

Cholesterol

Managing cholesterol is a major part of Ray Kurzweil’s long-term health strategy. He includes a range of natural and prescription-based options in his daily routine to support healthy lipid levels. Each supplement is selected based on research and adjusted with medical input to stay aligned with his overall goals.

• Grapefruit Powder: Supports lipid balance and is typically part of his breakfast routine. Found in several Ray Kurzweil supplements aimed at heart health.
• Guggulipid: Plant-based support for cholesterol control. Frequently listed in the Ray Kurzweil supplement list as a natural aid for blood fat management.
• Lecithin: Contributes to cholesterol support through fat metabolism. Included as part of the Phosphatidylcholine dosage in his daily stack.
• Oat Bran: Used to reduce LDL levels. Often part of his dietary supplements or mixed into meals to support heart health.
• Plant Sterols: Blocks cholesterol absorption in the intestines. A consistent entry in Ray Kurzweil diet supplements for managing cardiovascular risk.
• Policosanol: Helps maintain healthy cholesterol ratios. Found in the Ray Kurzweil health supplements lineup for added lipid support.
• Psyllium: Delivers soluble fiber to aid both cholesterol and digestion. Taken with water to improve consistency and absorption.
• Atorvastatin (prescription): Prescribed to control LDL levels and closely monitored. Combined with other supplements for a more complete approach.
• Vitamin B-3: Included for cardiovascular benefits and to support HDL levels. Adjusted based on test results within the Ray Kurzweil supplement list.

With this wide-ranging approach, it can help maintain heart function while supporting his vision for a longer, healthier life.

If you’re considering these supplements, speak with a healthcare professional to ensure it’s safe and appropriate for you.

Vitamins & Nutrients

A solid foundation of vitamins and essential nutrients supports every part of Ray Kurzweil’s health plan. These supplements ensure his body meets daily nutritional needs, making the rest of the supplements list more effective. He uses blood testing and regular reviews to fine-tune his intake and avoid deficiencies.

• Daily Multivitamin: Covers key vitamins and minerals. Taken each morning as part of the Ray Kurzweil daily supplements for general health maintenance.
• Vitamin B-12 Shots: Delivered at 1,000+ mcg weekly for detoxification and consistent energy. Often mentioned when people ask what supplements does Ray Kurzweil take regularly.
• L-Carnitine: Provides 1,000 mg daily to support cellular energy. A key component of the Ray Kurzweil diet supplements for metabolism.
• Vitamin D: Delivers 2,000 IU to support immune health and bones. Common in the Ray Kurzweil supplements list for people looking to maintain baseline wellness.

These essential nutrients form the backbone of the Ray Kurzweil supplements list. By covering nutritional gaps, they help ensure that every other supplement in his stack can function at its best.

I take about 250 supplements a day, including vitamins, minerals, antioxidants, and other nutrients.
Ray Kurzweil

General Health

To maintain full-body wellness, Ray Kurzweil includes a range of supplements that go beyond targeted categories like brain or heart health.

These support everyday functions such as immunity, detoxification, and antioxidant protection. He adjusts these based on seasonal needs and lab testing, keeping his supplement plan balanced and complete.

• Lycopene: 10 mg daily, taken with food to support cardiovascular health. Known for its antioxidant effects and often found in Ray Kurzweil supplements focused on heart wellness.
• N-Acetyl-L-Cysteine: 500 mg each day to promote respiratory and liver support. Included for its role in producing glutathione, a major antioxidant in the body.
• Silymarin (Milk Thistle): 200 mg daily to aid liver detoxification. This plant-based compound plays a supportive role in his overall liver health routine.
• Grape Seed Extract: Used to deliver additional antioxidants that protect against oxidative stress. Included for broad protection and often referenced in general health stacks.
• Echinacea: 500 mg daily during cold season to support immune response. Commonly rotated in the Ray Kurzweil health supplement routine during periods of higher risk.
• Garlic: 600 mg per day for wide-ranging benefits, including heart and immune support. A longtime addition to the Ray Kurzweil supplement list for general wellness.

Together, these supplements form a well-rounded set of nutrients designed to support daily vitality. They offer a protective buffer for everyday stressors, helping his broader supplement stack work even more effectively.

Although my program may seem extreme, it is actually conservative – and optimal (based on my current knowledge). My doctor and I have extensively researched each of the several hundred therapies that I use for safety and efficacy. I stay away from ideas that are unproven or appear to be risky.
Ray Kurzweil

Miscellaneous

Some supplements in Ray Kurzweil’s daily plan serve highly specific or emerging functions. These additions don’t fit neatly into one category but are still considered valuable for long-term wellness. Their use reflects his ongoing interest in newer research and how it can support future health outcomes.

• Alkaline Water: Consumed throughout the day to support acid-alkaline balance. While debated in science circles, it’s part of his personal hydration strategy.
• Glutathione: Used for cellular protection and antioxidant defense. Often discussed as part of the Ray Kurzweil health supplements for detox and immune support.
• Nicotinamide Riboside (NR): Added to enhance mitochondrial performance and energy output. Frequently linked to longevity-focused routines within the Ray Kurzweil supplements list.

These supplements represent a more experimental side of his routine—still supported by research but used in a more flexible, evolving way.

The Dave Asprey Supplement Overview

Longevity & Anti-Aging

• Nicotinamide Riboside (NR): Boosts cellular NAD⁺ levels for anti-aging and energy.
• Fisetin: Helps clear out “zombie” cells and fight inflammation.
• Collagen Protein: Supports youthful skin, joints, and gut health.
• Vitamin D3: Essential for longevity, immunity, and hormone balance.
• Vitamin K2: Ensures calcium goes to bones, not arteries, for heart health.
• Vitamin A: Key for immunity, vision, and skin health.
• Vitamin C: Powers collagen production and protects cells from aging.
• Vitamin E (tocopherols/tocotrienols): Shields cells from oxidative stress.
• Zinc & Copper: Keeps immune function strong and hormones balanced.
• Iodine: Supports metabolism and thyroid health.
• Omega-3 Fish/Krill Oil: Fights inflammation and keeps the brain sharp.
• Glutathione: The body’s master antioxidant for detox and longevity.
• PQQ (Pyrroloquinoline quinone): Fuels mitochondria and supports brain health.
• CoQ10: Essential for heart function and cellular energy.
• Polyphenols (from food & supplements): Plant compounds that activate longevity pathways.
• Curcumin: A powerful anti-inflammatory for brain and joint health.
• Apigenin: Helps preserve NAD⁺ levels and enhance cellular repair.
• Senolytics (Quercetin, Hydroxytyrosol): Clears aging cells for better health.

Cognitive Enhancement & Brain Function

• “Smart Mode” Nootropic: A powerhouse blend for focus and memory.
• Racetams (Aniracetam, Phenylpiracetam): Sharpens speech, recall, and mental speed.
• Modafinil (Provigil): Supercharges wakefulness and productivity.
• Microdoses (LSD, Psilocybin, Nicotine): Subtle cognitive boosts for creativity.
• Coffee & MCT (Bulletproof Coffee): The ultimate morning brain fuel.
• L-Tyrosine: Supports motivation, mood, and mental clarity.
• NeuroMaster (Coffee Fruit Extract): Increases BDNF to grow new brain cells.
• Eye Armor (Carotenoids & Antioxidants): Protects vision and brain health.
• Bacopa Monnieri: A time-tested herb for better memory and calm focus.
• Rosemary: Enhances circulation and cognitive function.
• Coleus Forskohlii: Boosts alertness and brain performance.

Energy & Metabolic Performance

• Brain Octane Oil (C8 MCT): Instant ketone fuel for brain and body.
• Unfair Advantage (CoQ10 + PQQ): Powers up mitochondria for peak energy.
• KetoPrime (Oxaloacetate): Supports metabolism and cellular energy production.
• Acetyl-L-Carnitine (ALCAR): Converts fat into fuel for sustained stamina.
• D-Ribose: Helps the body recover energy faster.
• Creatine: Strengthens muscles and sharpens cognitive function.
• Thyroid & Metabolic Support (Iodine, Selenium): Keeps metabolism and hormones in check.
• Caffeine & Nootropic Stacks (Dynamine, Rhodiola): Smooth energy without the jitters.
• Blood Sugar Stabilizers (Chromium, Berberine, Alpha-Lipoic Acid): Prevents energy crashes and supports metabolism.

Gut Health & Digestion

• Probiotics (Omni-Biotic Stress Release, Hetox, Power): Builds a healthier gut and stronger immunity.
• Prebiotic Fiber (InnerFuel Prebiotic – Acacia Gum, Larch Arabinogalactan): Feeds good gut bacteria for better digestion.
• Betaine HCl: Improves digestion and nutrient absorption.
• Digestive Enzymes (NOW Super Enzymes, MassZymes): Breaks down food for optimal gut health.
• Activated Charcoal: Binds toxins and reduces bloating.
• Gut Healing Nutrients (Collagen, L-Glutamine, Marshmallow Root, Aloe Vera): Repairs and strengthens the gut lining.
• Anti-Candida & GI Cleanup (Caprylic Acid, Berberine, Oregano Oil, Grapefruit Seed Extract): Wipes out bad bacteria and yeast overgrowth.
• Homebiotic (Probiotic Spray for Mold Control): Balances your home environment for better gut health.

Sleep Enhancement & Recovery

• Magnesium (Glycinate, Malate, Threonate, Citrate): Relaxes muscles and calms the mind for deep sleep.
• “Sleep Mode” (Melatonin + L-Ornithine): Supports natural sleep cycles without grogginess.
• Herbal Tranquilizers (Kava): Naturally soothes stress and promotes restful sleep.
• Phenibut (GABA Analog): Occasional deep sleep support and anxiety relief.
• 5-HTP: Boosts serotonin to improve relaxation and sleep quality.
• L-Theanine: Helps the brain wind down for a smooth transition into sleep.
• Glycine: Lowers body temperature for restorative rest.
• TrueDark Glasses & Sleep Hygiene Practices: Blocks blue light to enhance melatonin production.
• **Miscellaneous Sleep Aids (Tryptophan, Phosphatidylserine, Valerian, Chamomile, Lemon Balm, CBD):**Various tools for optimizing sleep naturally.

Stress Resilience & Mood Support

• Ashwagandha: Lowers cortisol and enhances stress resilience.
• L-Theanine: Keeps stress levels in check while improving focus.
• Omega-3 (EPA/DHA): Supports mood stability and cognitive health.
• 5-HTP: Increases serotonin to promote happiness and relaxation.
• Mucuna Pruriens (Velvet Bean): Naturally boosts dopamine for motivation.
• Magnesium: Helps the nervous system stay calm under pressure.
• Adaptogenic Herbs (Astragalus, He Shou Wu, Gynostemma): Strengthens the body’s response to stress.
• Kava: Reduces anxiety and promotes a peaceful mindset.
• “Happy” Brain Chemicals (DL-Phenylalanine, L-Phenylalanine, Vitamin B6, B12): Essential for neurotransmitter production.
• Mood Super-nutrients (Inositol, Lithium Orotate): Additional tools for emotional balance.
• Meditation, Breathing Exercises, Gratitude Practice: Lifestyle habits that enhance resilience naturally.

Hormones, Fitness & Sexual Health

• Maca Root: Naturally enhances libido and hormonal balance.
• Tribulus Terrestris: Supports sexual performance and androgen receptor function.
• Zinc & Copper: Essential for testosterone production and prostate health.
• Selenium: A key nutrient for thyroid and reproductive function.
• Vitamin D & K2: Boosts hormone levels and overall metabolic health.
• Creatine: Increases strength, endurance, and muscle mass.
• Branched-Chain Amino Acids (BCAAs) & Essential Amino Acids (EAAs): Helps preserve muscle while fasting.
• Carnitine (ALCAR): Enhances fat metabolism and energy levels.
• L-Arginine / Citrulline: Increases nitric oxide for better blood flow and performance.
• DIM (Diindolylmethane) & Calcium D-Glucarate: Helps balance estrogen and testosterone.
• Bone & Joint Support (Collagen, Omega-3s, Glucosamine, Chondroitin, Serrapeptase): Keeps joints strong and resilient.
• Unique Performance Hacks (CB-HD, Cordyceps, Caffeine + Yohimbine): Cutting-edge supplements for endurance and vitality.

Longevity & Anti-Aging

Dave Asprey has spent years refining his supplement stack to slow aging and support long-term health. His approach focuses on cellular function, reducing inflammation, and optimizing mitochondrial energy production. Instead of relying on a generic multivitamin, he selects individual compounds that provide specific benefits.

• Nicotinamide Riboside (NR): Supports cellular NAD⁺ production, which plays a role in energy metabolism and longevity. Asprey initially endorsed NR as a way to boost NAD⁺ levels, a molecule essential for mitochondrial health. However, as more research emerged, he noted concerns about its efficacy and shifted his preference toward nicotinamide mononucleotide (NMN) as a more effective option for longevity support.
• Fisetin: A polyphenol found in strawberries, fisetin is known for its ability to clear senescent (damaged) cells that contribute to aging and inflammation. Asprey calls it a “longevity substance” because of its senolytic properties, which help maintain cellular function. He includes fisetin in his anti-aging routine to promote healthier aging by reducing cellular debris and inflammation.
• Collagen Protein: A key part of Asprey’s daily supplement stack, collagen provides amino acids that support skin elasticity, joint function, and gut health. He recommends at least 10 grams per day, often blending Bulletproof Collagen into his coffee or smoothies. Collagen is especially beneficial for maintaining healthy connective tissues, which tend to weaken with age.
• Vitamin D3: Plays a critical role in immune function, bone health, and overall longevity. Asprey believes many people are deficient and takes 5,000 IU daily, significantly higher than the standard 400 IU found in most multivitamins. He highlights that adequate vitamin D levels are linked to reduced disease risk and better aging outcomes.
• Vitamin K2: Works alongside vitamin D3 to regulate calcium absorption, ensuring it is directed to bones rather than arteries. Asprey includes both MK-4 and MK-7 forms of K2 in his Vitamin ADK supplement. He stresses that without K2, taking vitamin D alone can lead to calcium buildup in soft tissues, increasing the risk of calcification.
• Vitamin A: Supports skin, vision, immune function, and cellular health. Asprey prefers the preformed version (retinyl palmitate) rather than beta-carotene, as some people cannot efficiently convert beta-carotene into active vitamin A. He typically takes 2,500 IU daily, often as part of his Vitamin ADK blend, since many people don’t consume enough organ meats, which are rich in vitamin A.
• Vitamin C: Plays a major role in collagen production, immune support, and mitochondrial function. Asprey takes at least 500 mg daily, emphasizing that vitamin C isn’t just an antioxidant but also helps regulate gene expression and metabolism. He also gets additional vitamin C from nutrient-dense foods like citrus fruits and leafy greens.
• Vitamin E (Tocopherols/Tocotrienols): Asprey prefers getting vitamin E from whole foods like nuts, seeds, and avocados rather than high-dose supplements. He warns that excessive amounts of isolated vitamin E may increase mortality risk. Instead of mega-dosing, he ensures he gets enough through diet or in a well-balanced multivitamin.
• Zinc & Copper: Essential for immune function, brain health, and antioxidant balance, these two minerals must be taken together to prevent deficiencies. Asprey takes 15–30 mg of zinc with a small amount of copper, as zinc can block copper absorption. He warns against taking too much of either, as excessive levels can become pro-oxidant rather than beneficial.
• Iodine: Supports thyroid function, metabolism, and hormone production. Asprey is a strong advocate of iodine supplementation, noting that many people are deficient due to modern diets. He takes 1,000 µg (1 mg) daily, often using iodine/iodide drops like Lugol’s solution to maintain optimal thyroid health.
• Omega-3 Fish/Krill Oil: Provides EPA and DHA, two fatty acids essential for brain health, heart function, and inflammation control. Asprey prefers krill oil over fish oil due to its superior bioavailability and phospholipid structure, which makes it easier for cells to absorb. He aims for 1,000 mg or more of combined EPA/DHA per day, often splitting doses between morning and evening.
• Glutathione: Known as the body’s master antioxidant, glutathione helps protect cells from oxidative stress and supports liver detoxification. Asprey takes liposomal glutathione or its precursor, N-acetyl-cysteine (NAC), which helps maintain glutathione levels. He often increases his intake when traveling or under stress to boost his body’s ability to detoxify.
• PQQ (Pyrroloquinoline Quinone): Supports mitochondrial health and cognitive function. Asprey includes 10 mg of PQQ in his Unfair Advantage supplement, a formula designed to enhance energy production at the cellular level. PQQ is known to stimulate new mitochondria growth, which may have longevity benefits.
• CoQ10: Works alongside PQQ to enhance mitochondrial energy production. Asprey takes at least 100 mg daily, often as ubiquinol, the more bioavailable form. He believes that supporting mitochondrial function is key to slowing aging, a topic he discusses extensively in his book Head Strong.
• Polyphenols: Found in coffee, green tea, dark chocolate, and berries, polyphenols have strong antioxidant and anti-inflammatory properties. Asprey created Polyphenomenal, a supplement that provides a concentrated dose of polyphenols to support cellular health and longevity. He believes these compounds activate pathways that help the body resist aging.
• Curcumin: The active ingredient in turmeric, curcumin has powerful anti-inflammatory and cognitive-supporting properties. Asprey takes a liposomal or black pepper-enhanced curcumin supplement to improve absorption. He acknowledges that while research on lifespan extension is mixed, curcumin still has significant health benefits.
• Apigenin: A flavonoid found in parsley and chamomile, apigenin may help enhance NAD⁺ levels by inhibiting CD38, an enzyme that depletes NAD. Asprey prefers getting apigenin from whole foods rather than supplements due to absorption challenges. He sees it as a potential longevity booster when used alongside NMN.
• Senolytics & Other Longevity Aids: Asprey has experimented with additional senolytics like quercetin (a flavonoid with anti-aging properties) and hydroxytyrosol (found in olive oil). He also advocates for advanced longevity therapies like hyperbaric oxygen, stem cell treatments, and peptides, although these fall outside the category of dietary supplements.

Asprey avoids most standard multivitamins, believing they contain poorly formulated ingredients or incorrect dosages. Instead, his Dave Asprey supplement recommendations focus on high-quality, bioavailable nutrients that specifically support longevity and cellular function.

Multivitamins contain too low doses… or the wrong combinations… Therefore, we recommend taking some essential vitamins and minerals separately.
Dave Asprey

Cognitive Enhancement & Brain Function

Dave Asprey has dedicated years to optimizing brain performance, experimenting with a mix of smart drugs, nootropics, and natural compounds. His approach focuses on improving focus, memory, and mental energy while minimizing cognitive fatigue. Many of his supplements are designed to support neurotransmitter balance, boost mitochondrial energy, and promote long-term brain health.

• Smart Mode Nootropic: To simplify his brain supplement routine, Asprey formulated Bulletproof Smart Mode, a nootropic stack designed to support focus, memory, and mental energy. It contains Citicoline, Artichoke Leaf Extract, Rosemary, Theacrine, N-Acetyl L-Tyrosine, and vitamin B5. He credits this formula with replacing the dozens of individual supplements he once took, saying it helps him stay mentally sharp every day.
• Racetams (Aniracetam & Phenylpiracetam): Asprey has used racetam nootropics for years. Aniracetam (650 mg once or twice daily) enhances memory, verbal fluency, and mental speed, while Phenylpiracetam (100 mg per dose, up to 3–4 times daily) provides an intense focus boost and increased physical energy. Since racetams may deplete choline, he often pairs them with citicoline or egg yolks to maintain balance.
• Modafinil: A prescription wakefulness enhancer, modafinil was a core part of Asprey’s biohacking supplements during his Silicon Valley days. He took 100 mg in the morning to combat fatigue and improve productivity. While modafinil helped him power through long work sessions, he cautions against overuse, noting it is intended for treating narcolepsy and should be used responsibly.
• Microdoses & Others: Asprey has experimented with microdoses of LSD and psilocybin for their potential effects on creativity and neuroplasticity. He has also tried low-dose nicotine (1 mg gum or lozenge) as a short-term focus booster. These aren’t daily habits but part of his past cognitive enhancement experiments.
• Coffee & MCT (Bulletproof Coffee): Asprey’s Bulletproof Coffee is one of his most famous brain supplements. The mix of high-quality coffee, grass-fed butter, and MCT oil provides clean mental energy without crashes. The Brain Octane Oil in it supports ketone production, fueling the brain with a more stable energy source than glucose.
• L-Tyrosine: This amino acid supports dopamine, epinephrine, and norepinephrine production, all essential for focus and motivation. Asprey takes 500–1,000 mg of L-tyrosine or its N-acetyl form in the morning to stay sharp, especially when under stress or lacking sleep. It is also included in his Smart Mode formula.
• NeuroMaster (Coffee Fruit Extract): Asprey developed NeuroMaster, a supplement based on coffee fruit extract, which can increase brain-derived neurotrophic factor (BDNF) by up to 140%. BDNF is essential for learning, memory, and neuron growth. He describes this supplement as “miracle grow for your brain” and takes 200 mg in the morning for a cognitive boost.
• Eye Armor (Carotenoids & Antioxidants): Asprey formulated Eye Armor to reduce eye strain and protect against oxidative stress. It contains lutein, zeaxanthin, and astaxanthin, which filter blue light and support retinal health. Since eye fatigue can impact mental performance, he takes this supplement daily to preserve vision and enhance brain function.
• Bacopa Monnieri & Herbal Nootropics: Asprey has praised Bacopa Monnieri, an Ayurvedic herb known for improving memory and reducing anxiety. He has taken ~300 mg of Bacopa extract daily in cycles to support recall and mental clarity. Other herbal nootropics in his stack include Rosemary (found in Smart Mode) and Coleus Forskohlii, which may enhance alertness by increasing cAMP levels in the brain.

Asprey’s brain supplement stack blends scientifically backed compounds with biohacker-driven experimentation. His Dave Asprey supplement recommendations emphasize sustained cognitive performance, neurotransmitter support, and mitochondrial energy production, making them a key part of his daily routine.

Energy & Metabolic Performance

Dave Asprey believes that optimizing energy production starts at the cellular level. His supplement choices focus on enhancing mitochondrial function, stabilizing blood sugar, and supporting metabolism to maintain high energy levels throughout the day. By improving how the body produces and utilizes energy, he aims to stay mentally sharp and physically active without the crashes caused by stimulants.

• Brain Octane Oil (C8 MCT): A staple in Asprey’s diet, Brain Octane Oil is a concentrated form of caprylic acid that converts rapidly into ketones, providing a quick energy boost. He adds it to coffee, smoothies, and meals to maintain stable energy levels and curb cravings. He notes that it raises blood ketones more efficiently than coconut oil, helping him stay in a fat-burning state.
• Unfair Advantage (CoQ10 + PQQ): This liquid supplement supports mitochondrial function by combining Coenzyme Q10 and PQQ. CoQ10 enhances ATP production, while PQQ promotes mitochondrial growth. Asprey takes one to two ampules in the morning or before mentally demanding tasks to improve endurance and cellular energy.
• KetoPrime (Oxaloacetate): A metabolic enhancer that supports mitochondrial efficiency. Asprey takes oxaloacetate in lozenge form, typically before workouts or in the morning, to help his body generate more energy. While he acknowledges that higher doses may be needed for maximum benefits, he still includes it in his stack for its potential to mimic calorie restriction effects.
• Acetyl-L-Carnitine (ALCAR): This amino acid helps transport fatty acids into mitochondria, allowing the body to use fat for fuel. Asprey takes between 500 and 1,000 mg in the morning, especially when fasting or following a ketogenic diet. It also supports nerve function and cognitive clarity, making it a valuable addition to his supplement routine.
• D-Ribose: A sugar molecule essential for ATP production. Asprey uses it to replenish cellular energy, particularly after workouts or intense mental exertion. He takes a few grams to aid muscle recovery and prevent fatigue, considering it a useful tool for maintaining steady energy levels.
• Creatine: A well-researched supplement for muscle strength and brain function. Asprey takes 3–5 grams daily to support ATP regeneration, helping both physical and cognitive performance. He finds it beneficial for maintaining muscle mass, especially during fasting or periods of reduced calorie intake.
• Thyroid & Metabolic Support: Asprey monitors his thyroid function closely, ensuring he gets enough iodine, selenium, and tyrosine to keep his metabolism running efficiently. While he has used prescription desiccated thyroid in the past, he mainly supports his thyroid naturally through supplements that promote hormone production.
• Caffeine & Nootropic Stacks: Beyond his morning coffee, Asprey sometimes takes energy-enhancing nootropics, including Dynamine (theacrine) and Rhodiola rosea, which help with adrenal support. He previously developed an energy drink called Fatwater, designed to provide a boost without sugar crashes.
• Blood Sugar Stabilizers: To maintain steady energy levels, Asprey includes supplements like chromium and berberine, which support insulin sensitivity. He also uses cinnamon extract and alpha-lipoic acid to regulate blood sugar, preventing energy dips after meals.

Asprey’s approach to energy supplements focuses on sustained performance rather than temporary boosts. His supplement stack is designed to keep metabolism efficient, prevent crashes, and support long-term mitochondrial health, making his routine a key part of his biohacking philosophy.

Gut Health & Digestion

Dave Asprey believes that a healthy gut is the foundation of overall wellness. He focuses on optimizing digestion, improving nutrient absorption, and maintaining a balanced microbiome. His supplement routine is designed to support every stage of digestion, from breaking down food efficiently to ensuring beneficial bacteria thrive.

• Probiotics: Asprey takes high-quality probiotics to maintain gut flora balance. He favors Omni-Biotic formulations, including Omni-Biotic Stress Release for gut-brain support, Omni-Biotic Hetox for liver detox, and Omni-Biotic Power for overall gut resilience. He typically takes probiotics on an empty stomach in the morning or before bed to enhance digestion, immunity, and mood.
• Prebiotic Fiber: To feed beneficial gut bacteria, Asprey formulated InnerFuel Prebiotic, which contains acacia gum, larch arabinogalactan, and guar fiber. He mixes a scoop into his coffee or smoothie daily to promote gut lining health and short-chain fatty acid production, which helps reduce inflammation. He emphasizes that prebiotics have a longer-lasting effect on gut health than probiotics alone.
• Betaine HCl: To aid digestion, Asprey takes 1–2 capsules of betaine HCl with pepsin at the start of larger meals. He found this particularly useful for improving stomach acid levels, which helps break down protein and absorb essential nutrients like B12 and iron. He credits this supplement with preventing bloating and indigestion, especially when eating heavier meals.
• Digestive Enzymes: Asprey uses digestive enzymes to help break down proteins, fats, and carbohydrates. He has taken brands like NOW Super Enzymes and MassZymes to maximize nutrient absorption. When consuming harder-to-digest foods like steak, he pairs digestive enzymes with betaine HCl to support smoother digestion.
• Activated Charcoal: As a defense against food toxins and bloating, Asprey regularly takes activated charcoal capsules, particularly when eating out. He uses 1,000 mg of coconut-shell activated charcoal to bind potential toxins and reduce digestive discomfort. While it won’t prevent alcohol’s cognitive effects, he finds it helpful in minimizing food-related reactions and inflammation.
• Gut Healing Nutrients: Asprey supports gut lining health with collagen and L-glutamine. He highlights that collagen peptides help repair the intestinal lining, especially in cases of inflammation. He also includes bone broth, gelatin, marshmallow root, and aloe vera in his diet to soothe and strengthen gut tissue.
• Anti-Candida and GI Cleanup: To combat gut imbalances, Asprey occasionally takes caprylic acid, berberine, oregano oil, or grapefruit seed extract. He also uses bentonite clay and activated charcoal to detoxify the gut when necessary. These supplements are part of his gut detox protocols aimed at keeping harmful microbes under control.
• Homebiotic & Mold Control: Asprey takes an environmental approach to gut health by minimizing mold exposure in his home. He uses Homebiotic spray, a probiotic-based product designed to reduce mold growth, as he believes mold toxins can negatively impact digestion and immune function.

Asprey’s gut health routine reflects his belief that digestion impacts everything from immunity to mental clarity. By combining probiotics, prebiotics, enzymes, and detoxifiers, he aims to maintain a strong gut microbiome and ensure optimal nutrient absorption.

I usually take a capsule of betaine HCl with meals to increase my stomach acid for better digestion.
Dave Asprey

Sleep Enhancement & Recovery

Dave Asprey views high-quality sleep as one of the most important factors for longevity and daily performance. He focuses on optimizing his body’s ability to relax, regulate hormones, and enter deep sleep stages efficiently. His supplement routine is designed to calm the nervous system, support melatonin production, and improve overall sleep quality without relying on heavy sedatives.

• Magnesium (Various Forms): Asprey considers magnesium essential for both relaxation and overall health. He takes around 600–800 mg daily in different forms, such as glycinate, malate, and threonate. At night, he prefers magnesium glycinate or citrate to relax muscles and promote deeper sleep. In the morning, he takes other forms like malate or orotate for energy support. He often recommends Natural Calm (magnesium citrate) or Magnesium L-Threonate for their brain-boosting benefits.
• “Sleep Mode” (Melatonin + L-Ornithine): To regulate his sleep-wake cycle without high doses of melatonin, Asprey formulated Sleep Mode, which contains 0.3 mg of melatonin, L-ornithine, and herbal extracts. He takes two softgels at bedtime, noting that this low-dose melatonin helps nudge his circadian rhythm without causing grogginess the next day. L-ornithine helps lower cortisol levels, making it easier to unwind before sleep.
• Herbal Tranquilizers (Kava): Asprey occasionally drinks kava tea or takes kava extract in the evenings to relax. He describes kava as a strong herbal sedative that increases GABA activity in the brain, helping reduce stress and tension. He prefers Yogi Kava Stress Relief tea or kava extract capsules, sometimes pairing them with a teaspoon of Brain Octane Oil for better absorption.
• Phenibut (GABA Analog): When struggling with extreme stress or jet lag, Asprey has used phenibut, a synthetic form of GABA that crosses the blood-brain barrier. He follows strict guidelines, taking only 250 mg no more than 1–2 times per week and cycling off completely for extended periods to avoid dependency. He warns that phenibut should never be mixed with alcohol due to its potent effects on GABA receptors.
• 5-HTP: Asprey takes 5-HTP to support serotonin production, which converts into melatonin at night. He typically takes 50–100 mg in the evening to enhance mood and promote restful sleep. He also mentions that 5-HTP can be used throughout the day in small doses to help with stress resilience.
• L-Theanine: Known for promoting relaxation without sedation, L-theanine is a key part of Asprey’s routine. He usually takes 200 mg in the daytime to smooth out caffeine’s effects but sometimes uses it in the evening if he feels wired. It helps lower stress while allowing for a calm, clear-headed state before sleep.
• Glycine: Asprey sometimes takes 3 grams of glycine at night to improve sleep quality and regulate body temperature. He often gets glycine naturally from collagen, which he consumes before bed in drinks like hot chocolate or bone broth. This amino acid supports deeper sleep by relaxing the nervous system.
• Truedark Glasses & Sleep Hygiene: While not a supplement, Asprey wears TrueDark red-lens glasses in the evening to block blue light and support natural melatonin production. He also optimizes his sleep environment by using a cooling mattress, blackout curtains, and temperature regulation tools like chiliPAD or Eight Sleep.
• Miscellaneous Sleep Aids: Asprey occasionally experiments with tryptophan, phosphatidylserine (to lower nighttime cortisol), and herbal blends like valerian, chamomile, and lemon balm. He has also used CBD tinctures for relaxation but emphasizes the importance of sourcing high-quality, toxin-free products.

Asprey’s sleep supplement stack reflects his philosophy of optimizing rest without relying on excessive doses or sedatives. By supporting neurotransmitter function, reducing stress hormones, and maintaining proper sleep hygiene, he aims to improve deep sleep quality and overall recovery efficiency.

I take as many different forms as I can get. I’ve got eight different forms [of magnesium].
Dave Asprey

Stress Resilience & Mood Support

Dave Asprey prioritizes stress management and emotional balance as essential components of peak performance. His supplement regimen includes adaptogens, amino acids, and neurotransmitter precursors that help him stay focused, reduce cortisol levels, and maintain a positive mood. By supporting brain chemistry and nervous system regulation, these supplements contribute to his ability to handle pressure while staying mentally sharp.

• Ashwagandha: This adaptogenic herb helps reduce cortisol levels and increase stress resilience. Asprey takes 500–1000 mg of a high-potency extract like KSM-66 or Sensoril in the morning to promote relaxation and prevent burnout. He considers ashwagandha a daily staple, especially during intense work periods or travel.
• L-Theanine: A natural amino acid found in tea, L-theanine helps create a sense of calm without sedation. Asprey takes 200 mg in the morning with his coffee to smooth out caffeine’s stimulating effects. On stressful days, he may take an additional 200 mg in the afternoon to stay relaxed and improve focus.
• Omega-3 (EPA/DHA): Omega-3 fatty acids from krill oil play a role in brain function and mood regulation. Asprey takes 1–2 grams daily, ensuring a higher EPA-to-DHA ratio for its mood-supporting effects. He finds that adequate omega-3 intake helps keep his mind clear and his mood stable.
• 5-HTP: This serotonin precursor helps support emotional well-being and relaxation. Asprey recommends 50 mg taken multiple times per day, up to six times daily, to maintain balanced serotonin levels. He particularly relies on 5-HTP during winter months or when adjusting to new time zones.
• Mucuna Pruriens (Velvet Bean): A natural source of L-DOPA, mucuna pruriens supports dopamine production, which influences motivation and mood. Asprey takes 100–200 mg of mucuna extract to maintain optimal dopamine levels, especially after periods of prolonged stress.
• Magnesium: Beyond its sleep benefits, magnesium is critical for mood regulation and stress reduction. Asprey supplements with 400–600 mg daily in various forms, ensuring he gets enough to support serotonin production and nervous system function.
• Adaptogenic Herbs: Asprey includes additional adaptogens in his routine for their stress-protective effects:
  • Astragalus: He takes 500 mg to support immune function and protect mitochondria from stress-related damage.
  • He Shou Wu (Fo-Ti): Occasionally used for its brain and liver benefits, Asprey takes 560 mg of this traditional Chinese herb to maintain cognitive resilience.
  • Gynostemma (Jiaogulan): This herb may enhance alpha brain wave activity, promoting a meditative state. Asprey takes 250 mg as a tea or capsule with a fat source for better absorption.
• Kava: Asprey uses kava extract as a natural anxiolytic, comparing its effects to pharmaceutical anti-anxiety medications without sedation. He drinks kava tea or takes a capsule in the morning or before stressful events to promote relaxation while maintaining mental clarity.
• “Happy” Brain Chemicals: To support neurotransmitter production, Asprey occasionally supplements with DL-Phenylalanine or L-Phenylalanine for dopamine and endorphin production. He also takes methylated forms of vitamin B6 and B12 to aid neurotransmitter synthesis.
• Mood Super-nutrients: Asprey has experimented with additional nutrients like inositol (vitamin B8) for anxiety and lithium orotate (5 mg) for mood stabilization. While not daily essentials, he considers them useful tools for specific situations.
• Social and Environmental Factors: Beyond supplements, Asprey emphasizes meditation, controlled breathing, and gratitude practices to enhance resilience. He also uses a soundproof relaxation space at home to further reduce stress levels.

Asprey’s supplement stack for stress and mood is designed to keep cortisol levels in check, optimize neurotransmitters, and promote emotional stability. By combining adaptogens, targeted nutrients, and mindfulness practices, he ensures that stress doesn’t interfere with performance or overall well-being.

Hormones, Fitness & Sexual Health

Dave Asprey takes a proactive approach to maintaining hormonal balance, physical performance, and sexual health. His supplement regimen includes natural compounds that support testosterone levels, muscle preservation, and overall vitality. By combining amino acids, adaptogens, and targeted nutrients, he aims to optimize energy, endurance, and long-term hormonal function.

• Maca Root: Asprey uses gelatinized maca powder, taking 3–5 grams daily for its libido-enhancing and hormone-supporting properties. He adds it to smoothies or coffee, citing its benefits for both men and women. He emphasizes the importance of high-quality sourcing to avoid contamination with mold.
• Tribulus Terrestris: Known for its potential to enhance libido and circulation, Tribulus terrestris is part of Asprey’s routine when needed. He takes 1,000 mg of Tribulus extract, typically in the morning or before sexual activity. While it doesn’t directly raise testosterone, it may support androgen receptor function.
• Zinc & Other Male Health Nutrients: Asprey ensures proper testosterone support with 15–30 mg of zinc, balancing it with copper to avoid deficiencies. He also includes selenium, either through Brazil nuts or a 200 mcg supplement, to aid thyroid and reproductive health.
• Vitamin D & K2: Asprey takes 5,000 IU of vitamin D3 daily, which plays a critical role in testosterone production and metabolic health. He pairs it with vitamin K2 in his ADK supplement to ensure proper calcium utilization.
• Creatine & Aminos for Muscle: To maintain muscle strength, Asprey supplements with creatine monohydrate. He also includes branched-chain amino acids (BCAAs) or essential amino acids (EAAs) around workouts while ensuring he doesn’t overconsume them to preserve autophagy benefits during fasting.
• Carnitine & L-Arginine: Acetyl-L-carnitine (ALCAR) aids fat metabolism and energy production, while also supporting sperm motility. Asprey may also use L-arginine or citrulline for their nitric oxide-boosting effects, which enhance circulation and performance.
• Hormone Replacement Adjuncts: While Asprey has used testosterone replacement therapy (TRT), he also takes supplements like DIM (Diindolylmethane) and calcium D-glucarate to regulate estrogen metabolism. He includes cruciferous vegetables in his diet to further support hormonal balance.
• Bone & Joint Support: Asprey maintains joint health with collagen and omega-3s, which help reduce inflammation. He may also use glucosamine and chondroitin for cartilage support, along with systemic enzymes like serrapeptase to aid recovery.
• Unique Performance Hacks: Asprey has experimented with various performance enhancers, including CB-HD (a cannabinoid) for pre-workout, Cordyceps mushroom for endurance, and caffeine with yohimbine for fasted cardio. He continuously evaluates new supplements while sticking to core strategies that support long-term vitality.

Asprey’s supplement stack for hormones, fitness, and sexual health focuses on maintaining youthful energy, optimizing physical performance, and ensuring long-term well-being. By using natural compounds and essential nutrients, he supports his body’s ability to stay strong, resilient, and hormonally balanced.

You get the right supplements in the right [body], magic happens.
Dave Asprey