Dave Asprey’s Supplement List

The Dave Asprey Supplement Overview

Longevity & Anti-Aging

• Nicotinamide Riboside (NR): Boosts cellular NAD⁺ levels for anti-aging and energy.
• Fisetin: Helps clear out “zombie” cells and fight inflammation.
• Collagen Protein: Supports youthful skin, joints, and gut health.
• Vitamin D3: Essential for longevity, immunity, and hormone balance.
• Vitamin K2: Ensures calcium goes to bones, not arteries, for heart health.
• Vitamin A: Key for immunity, vision, and skin health.
• Vitamin C: Powers collagen production and protects cells from aging.
• Vitamin E (tocopherols/tocotrienols): Shields cells from oxidative stress.
• Zinc & Copper: Keeps immune function strong and hormones balanced.
• Iodine: Supports metabolism and thyroid health.
• Omega-3 Fish/Krill Oil: Fights inflammation and keeps the brain sharp.
• Glutathione: The body’s master antioxidant for detox and longevity.
• PQQ (Pyrroloquinoline quinone): Fuels mitochondria and supports brain health.
• CoQ10: Essential for heart function and cellular energy.
• Polyphenols (from food & supplements): Plant compounds that activate longevity pathways.
• Curcumin: A powerful anti-inflammatory for brain and joint health.
• Apigenin: Helps preserve NAD⁺ levels and enhance cellular repair.
• Senolytics (Quercetin, Hydroxytyrosol): Clears aging cells for better health.

Cognitive Enhancement & Brain Function

• “Smart Mode” Nootropic: A powerhouse blend for focus and memory.
• Racetams (Aniracetam, Phenylpiracetam): Sharpens speech, recall, and mental speed.
• Modafinil (Provigil): Supercharges wakefulness and productivity.
• Microdoses (LSD, Psilocybin, Nicotine): Subtle cognitive boosts for creativity.
• Coffee & MCT (Bulletproof Coffee): The ultimate morning brain fuel.
• L-Tyrosine: Supports motivation, mood, and mental clarity.
• NeuroMaster (Coffee Fruit Extract): Increases BDNF to grow new brain cells.
• Eye Armor (Carotenoids & Antioxidants): Protects vision and brain health.
• Bacopa Monnieri: A time-tested herb for better memory and calm focus.
• Rosemary: Enhances circulation and cognitive function.
• Coleus Forskohlii: Boosts alertness and brain performance.

Energy & Metabolic Performance

• Brain Octane Oil (C8 MCT): Instant ketone fuel for brain and body.
• Unfair Advantage (CoQ10 + PQQ): Powers up mitochondria for peak energy.
• KetoPrime (Oxaloacetate): Supports metabolism and cellular energy production.
• Acetyl-L-Carnitine (ALCAR): Converts fat into fuel for sustained stamina.
• D-Ribose: Helps the body recover energy faster.
• Creatine: Strengthens muscles and sharpens cognitive function.
• Thyroid & Metabolic Support (Iodine, Selenium): Keeps metabolism and hormones in check.
• Caffeine & Nootropic Stacks (Dynamine, Rhodiola): Smooth energy without the jitters.
• Blood Sugar Stabilizers (Chromium, Berberine, Alpha-Lipoic Acid): Prevents energy crashes and supports metabolism.

Gut Health & Digestion

• Probiotics (Omni-Biotic Stress Release, Hetox, Power): Builds a healthier gut and stronger immunity.
• Prebiotic Fiber (InnerFuel Prebiotic – Acacia Gum, Larch Arabinogalactan): Feeds good gut bacteria for better digestion.
• Betaine HCl: Improves digestion and nutrient absorption.
• Digestive Enzymes (NOW Super Enzymes, MassZymes): Breaks down food for optimal gut health.
• Activated Charcoal: Binds toxins and reduces bloating.
• Gut Healing Nutrients (Collagen, L-Glutamine, Marshmallow Root, Aloe Vera): Repairs and strengthens the gut lining.
• Anti-Candida & GI Cleanup (Caprylic Acid, Berberine, Oregano Oil, Grapefruit Seed Extract): Wipes out bad bacteria and yeast overgrowth.
• Homebiotic (Probiotic Spray for Mold Control): Balances your home environment for better gut health.

Sleep Enhancement & Recovery

• Magnesium (Glycinate, Malate, Threonate, Citrate): Relaxes muscles and calms the mind for deep sleep.
• “Sleep Mode” (Melatonin + L-Ornithine): Supports natural sleep cycles without grogginess.
• Herbal Tranquilizers (Kava): Naturally soothes stress and promotes restful sleep.
• Phenibut (GABA Analog): Occasional deep sleep support and anxiety relief.
• 5-HTP: Boosts serotonin to improve relaxation and sleep quality.
• L-Theanine: Helps the brain wind down for a smooth transition into sleep.
• Glycine: Lowers body temperature for restorative rest.
• TrueDark Glasses & Sleep Hygiene Practices: Blocks blue light to enhance melatonin production.
• **Miscellaneous Sleep Aids (Tryptophan, Phosphatidylserine, Valerian, Chamomile, Lemon Balm, CBD):**Various tools for optimizing sleep naturally.

Stress Resilience & Mood Support

• Ashwagandha: Lowers cortisol and enhances stress resilience.
• L-Theanine: Keeps stress levels in check while improving focus.
• Omega-3 (EPA/DHA): Supports mood stability and cognitive health.
• 5-HTP: Increases serotonin to promote happiness and relaxation.
• Mucuna Pruriens (Velvet Bean): Naturally boosts dopamine for motivation.
• Magnesium: Helps the nervous system stay calm under pressure.
• Adaptogenic Herbs (Astragalus, He Shou Wu, Gynostemma): Strengthens the body’s response to stress.
• Kava: Reduces anxiety and promotes a peaceful mindset.
• “Happy” Brain Chemicals (DL-Phenylalanine, L-Phenylalanine, Vitamin B6, B12): Essential for neurotransmitter production.
• Mood Super-nutrients (Inositol, Lithium Orotate): Additional tools for emotional balance.
• Meditation, Breathing Exercises, Gratitude Practice: Lifestyle habits that enhance resilience naturally.

Hormones, Fitness & Sexual Health

• Maca Root: Naturally enhances libido and hormonal balance.
• Tribulus Terrestris: Supports sexual performance and androgen receptor function.
• Zinc & Copper: Essential for testosterone production and prostate health.
• Selenium: A key nutrient for thyroid and reproductive function.
• Vitamin D & K2: Boosts hormone levels and overall metabolic health.
• Creatine: Increases strength, endurance, and muscle mass.
• Branched-Chain Amino Acids (BCAAs) & Essential Amino Acids (EAAs): Helps preserve muscle while fasting.
• Carnitine (ALCAR): Enhances fat metabolism and energy levels.
• L-Arginine / Citrulline: Increases nitric oxide for better blood flow and performance.
• DIM (Diindolylmethane) & Calcium D-Glucarate: Helps balance estrogen and testosterone.
• Bone & Joint Support (Collagen, Omega-3s, Glucosamine, Chondroitin, Serrapeptase): Keeps joints strong and resilient.
• Unique Performance Hacks (CB-HD, Cordyceps, Caffeine + Yohimbine): Cutting-edge supplements for endurance and vitality.

Longevity & Anti-Aging

Dave Asprey has spent years refining his supplement stack to slow aging and support long-term health. His approach focuses on cellular function, reducing inflammation, and optimizing mitochondrial energy production. Instead of relying on a generic multivitamin, he selects individual compounds that provide specific benefits.

• Nicotinamide Riboside (NR): Supports cellular NAD⁺ production, which plays a role in energy metabolism and longevity. Asprey initially endorsed NR as a way to boost NAD⁺ levels, a molecule essential for mitochondrial health. However, as more research emerged, he noted concerns about its efficacy and shifted his preference toward nicotinamide mononucleotide (NMN) as a more effective option for longevity support.
• Fisetin: A polyphenol found in strawberries, fisetin is known for its ability to clear senescent (damaged) cells that contribute to aging and inflammation. Asprey calls it a “longevity substance” because of its senolytic properties, which help maintain cellular function. He includes fisetin in his anti-aging routine to promote healthier aging by reducing cellular debris and inflammation.
• Collagen Protein: A key part of Asprey’s daily supplement stack, collagen provides amino acids that support skin elasticity, joint function, and gut health. He recommends at least 10 grams per day, often blending Bulletproof Collagen into his coffee or smoothies. Collagen is especially beneficial for maintaining healthy connective tissues, which tend to weaken with age.
• Vitamin D3: Plays a critical role in immune function, bone health, and overall longevity. Asprey believes many people are deficient and takes 5,000 IU daily, significantly higher than the standard 400 IU found in most multivitamins. He highlights that adequate vitamin D levels are linked to reduced disease risk and better aging outcomes.
• Vitamin K2: Works alongside vitamin D3 to regulate calcium absorption, ensuring it is directed to bones rather than arteries. Asprey includes both MK-4 and MK-7 forms of K2 in his Vitamin ADK supplement. He stresses that without K2, taking vitamin D alone can lead to calcium buildup in soft tissues, increasing the risk of calcification.
• Vitamin A: Supports skin, vision, immune function, and cellular health. Asprey prefers the preformed version (retinyl palmitate) rather than beta-carotene, as some people cannot efficiently convert beta-carotene into active vitamin A. He typically takes 2,500 IU daily, often as part of his Vitamin ADK blend, since many people don’t consume enough organ meats, which are rich in vitamin A.
• Vitamin C: Plays a major role in collagen production, immune support, and mitochondrial function. Asprey takes at least 500 mg daily, emphasizing that vitamin C isn’t just an antioxidant but also helps regulate gene expression and metabolism. He also gets additional vitamin C from nutrient-dense foods like citrus fruits and leafy greens.
• Vitamin E (Tocopherols/Tocotrienols): Asprey prefers getting vitamin E from whole foods like nuts, seeds, and avocados rather than high-dose supplements. He warns that excessive amounts of isolated vitamin E may increase mortality risk. Instead of mega-dosing, he ensures he gets enough through diet or in a well-balanced multivitamin.
• Zinc & Copper: Essential for immune function, brain health, and antioxidant balance, these two minerals must be taken together to prevent deficiencies. Asprey takes 15–30 mg of zinc with a small amount of copper, as zinc can block copper absorption. He warns against taking too much of either, as excessive levels can become pro-oxidant rather than beneficial.
• Iodine: Supports thyroid function, metabolism, and hormone production. Asprey is a strong advocate of iodine supplementation, noting that many people are deficient due to modern diets. He takes 1,000 µg (1 mg) daily, often using iodine/iodide drops like Lugol’s solution to maintain optimal thyroid health.
• Omega-3 Fish/Krill Oil: Provides EPA and DHA, two fatty acids essential for brain health, heart function, and inflammation control. Asprey prefers krill oil over fish oil due to its superior bioavailability and phospholipid structure, which makes it easier for cells to absorb. He aims for 1,000 mg or more of combined EPA/DHA per day, often splitting doses between morning and evening.
• Glutathione: Known as the body’s master antioxidant, glutathione helps protect cells from oxidative stress and supports liver detoxification. Asprey takes liposomal glutathione or its precursor, N-acetyl-cysteine (NAC), which helps maintain glutathione levels. He often increases his intake when traveling or under stress to boost his body’s ability to detoxify.
• PQQ (Pyrroloquinoline Quinone): Supports mitochondrial health and cognitive function. Asprey includes 10 mg of PQQ in his Unfair Advantage supplement, a formula designed to enhance energy production at the cellular level. PQQ is known to stimulate new mitochondria growth, which may have longevity benefits.
• CoQ10: Works alongside PQQ to enhance mitochondrial energy production. Asprey takes at least 100 mg daily, often as ubiquinol, the more bioavailable form. He believes that supporting mitochondrial function is key to slowing aging, a topic he discusses extensively in his book Head Strong.
• Polyphenols: Found in coffee, green tea, dark chocolate, and berries, polyphenols have strong antioxidant and anti-inflammatory properties. Asprey created Polyphenomenal, a supplement that provides a concentrated dose of polyphenols to support cellular health and longevity. He believes these compounds activate pathways that help the body resist aging.
• Curcumin: The active ingredient in turmeric, curcumin has powerful anti-inflammatory and cognitive-supporting properties. Asprey takes a liposomal or black pepper-enhanced curcumin supplement to improve absorption. He acknowledges that while research on lifespan extension is mixed, curcumin still has significant health benefits.
• Apigenin: A flavonoid found in parsley and chamomile, apigenin may help enhance NAD⁺ levels by inhibiting CD38, an enzyme that depletes NAD. Asprey prefers getting apigenin from whole foods rather than supplements due to absorption challenges. He sees it as a potential longevity booster when used alongside NMN.
• Senolytics & Other Longevity Aids: Asprey has experimented with additional senolytics like quercetin (a flavonoid with anti-aging properties) and hydroxytyrosol (found in olive oil). He also advocates for advanced longevity therapies like hyperbaric oxygen, stem cell treatments, and peptides, although these fall outside the category of dietary supplements.

Asprey avoids most standard multivitamins, believing they contain poorly formulated ingredients or incorrect dosages. Instead, his Dave Asprey supplement recommendations focus on high-quality, bioavailable nutrients that specifically support longevity and cellular function.

Multivitamins contain too low doses… or the wrong combinations… Therefore, we recommend taking some essential vitamins and minerals separately.
Dave Asprey

Cognitive Enhancement & Brain Function

Dave Asprey has dedicated years to optimizing brain performance, experimenting with a mix of smart drugs, nootropics, and natural compounds. His approach focuses on improving focus, memory, and mental energy while minimizing cognitive fatigue. Many of his supplements are designed to support neurotransmitter balance, boost mitochondrial energy, and promote long-term brain health.

• Smart Mode Nootropic: To simplify his brain supplement routine, Asprey formulated Bulletproof Smart Mode, a nootropic stack designed to support focus, memory, and mental energy. It contains Citicoline, Artichoke Leaf Extract, Rosemary, Theacrine, N-Acetyl L-Tyrosine, and vitamin B5. He credits this formula with replacing the dozens of individual supplements he once took, saying it helps him stay mentally sharp every day.
• Racetams (Aniracetam & Phenylpiracetam): Asprey has used racetam nootropics for years. Aniracetam (650 mg once or twice daily) enhances memory, verbal fluency, and mental speed, while Phenylpiracetam (100 mg per dose, up to 3–4 times daily) provides an intense focus boost and increased physical energy. Since racetams may deplete choline, he often pairs them with citicoline or egg yolks to maintain balance.
• Modafinil: A prescription wakefulness enhancer, modafinil was a core part of Asprey’s biohacking supplements during his Silicon Valley days. He took 100 mg in the morning to combat fatigue and improve productivity. While modafinil helped him power through long work sessions, he cautions against overuse, noting it is intended for treating narcolepsy and should be used responsibly.
• Microdoses & Others: Asprey has experimented with microdoses of LSD and psilocybin for their potential effects on creativity and neuroplasticity. He has also tried low-dose nicotine (1 mg gum or lozenge) as a short-term focus booster. These aren’t daily habits but part of his past cognitive enhancement experiments.
• Coffee & MCT (Bulletproof Coffee): Asprey’s Bulletproof Coffee is one of his most famous brain supplements. The mix of high-quality coffee, grass-fed butter, and MCT oil provides clean mental energy without crashes. The Brain Octane Oil in it supports ketone production, fueling the brain with a more stable energy source than glucose.
• L-Tyrosine: This amino acid supports dopamine, epinephrine, and norepinephrine production, all essential for focus and motivation. Asprey takes 500–1,000 mg of L-tyrosine or its N-acetyl form in the morning to stay sharp, especially when under stress or lacking sleep. It is also included in his Smart Mode formula.
• NeuroMaster (Coffee Fruit Extract): Asprey developed NeuroMaster, a supplement based on coffee fruit extract, which can increase brain-derived neurotrophic factor (BDNF) by up to 140%. BDNF is essential for learning, memory, and neuron growth. He describes this supplement as “miracle grow for your brain” and takes 200 mg in the morning for a cognitive boost.
• Eye Armor (Carotenoids & Antioxidants): Asprey formulated Eye Armor to reduce eye strain and protect against oxidative stress. It contains lutein, zeaxanthin, and astaxanthin, which filter blue light and support retinal health. Since eye fatigue can impact mental performance, he takes this supplement daily to preserve vision and enhance brain function.
• Bacopa Monnieri & Herbal Nootropics: Asprey has praised Bacopa Monnieri, an Ayurvedic herb known for improving memory and reducing anxiety. He has taken ~300 mg of Bacopa extract daily in cycles to support recall and mental clarity. Other herbal nootropics in his stack include Rosemary (found in Smart Mode) and Coleus Forskohlii, which may enhance alertness by increasing cAMP levels in the brain.

Asprey’s brain supplement stack blends scientifically backed compounds with biohacker-driven experimentation. His Dave Asprey supplement recommendations emphasize sustained cognitive performance, neurotransmitter support, and mitochondrial energy production, making them a key part of his daily routine.

Energy & Metabolic Performance

Dave Asprey believes that optimizing energy production starts at the cellular level. His supplement choices focus on enhancing mitochondrial function, stabilizing blood sugar, and supporting metabolism to maintain high energy levels throughout the day. By improving how the body produces and utilizes energy, he aims to stay mentally sharp and physically active without the crashes caused by stimulants.

• Brain Octane Oil (C8 MCT): A staple in Asprey’s diet, Brain Octane Oil is a concentrated form of caprylic acid that converts rapidly into ketones, providing a quick energy boost. He adds it to coffee, smoothies, and meals to maintain stable energy levels and curb cravings. He notes that it raises blood ketones more efficiently than coconut oil, helping him stay in a fat-burning state.
• Unfair Advantage (CoQ10 + PQQ): This liquid supplement supports mitochondrial function by combining Coenzyme Q10 and PQQ. CoQ10 enhances ATP production, while PQQ promotes mitochondrial growth. Asprey takes one to two ampules in the morning or before mentally demanding tasks to improve endurance and cellular energy.
• KetoPrime (Oxaloacetate): A metabolic enhancer that supports mitochondrial efficiency. Asprey takes oxaloacetate in lozenge form, typically before workouts or in the morning, to help his body generate more energy. While he acknowledges that higher doses may be needed for maximum benefits, he still includes it in his stack for its potential to mimic calorie restriction effects.
• Acetyl-L-Carnitine (ALCAR): This amino acid helps transport fatty acids into mitochondria, allowing the body to use fat for fuel. Asprey takes between 500 and 1,000 mg in the morning, especially when fasting or following a ketogenic diet. It also supports nerve function and cognitive clarity, making it a valuable addition to his supplement routine.
• D-Ribose: A sugar molecule essential for ATP production. Asprey uses it to replenish cellular energy, particularly after workouts or intense mental exertion. He takes a few grams to aid muscle recovery and prevent fatigue, considering it a useful tool for maintaining steady energy levels.
• Creatine: A well-researched supplement for muscle strength and brain function. Asprey takes 3–5 grams daily to support ATP regeneration, helping both physical and cognitive performance. He finds it beneficial for maintaining muscle mass, especially during fasting or periods of reduced calorie intake.
• Thyroid & Metabolic Support: Asprey monitors his thyroid function closely, ensuring he gets enough iodine, selenium, and tyrosine to keep his metabolism running efficiently. While he has used prescription desiccated thyroid in the past, he mainly supports his thyroid naturally through supplements that promote hormone production.
• Caffeine & Nootropic Stacks: Beyond his morning coffee, Asprey sometimes takes energy-enhancing nootropics, including Dynamine (theacrine) and Rhodiola rosea, which help with adrenal support. He previously developed an energy drink called Fatwater, designed to provide a boost without sugar crashes.
• Blood Sugar Stabilizers: To maintain steady energy levels, Asprey includes supplements like chromium and berberine, which support insulin sensitivity. He also uses cinnamon extract and alpha-lipoic acid to regulate blood sugar, preventing energy dips after meals.

Asprey’s approach to energy supplements focuses on sustained performance rather than temporary boosts. His supplement stack is designed to keep metabolism efficient, prevent crashes, and support long-term mitochondrial health, making his routine a key part of his biohacking philosophy.

Gut Health & Digestion

Dave Asprey believes that a healthy gut is the foundation of overall wellness. He focuses on optimizing digestion, improving nutrient absorption, and maintaining a balanced microbiome. His supplement routine is designed to support every stage of digestion, from breaking down food efficiently to ensuring beneficial bacteria thrive.

• Probiotics: Asprey takes high-quality probiotics to maintain gut flora balance. He favors Omni-Biotic formulations, including Omni-Biotic Stress Release for gut-brain support, Omni-Biotic Hetox for liver detox, and Omni-Biotic Power for overall gut resilience. He typically takes probiotics on an empty stomach in the morning or before bed to enhance digestion, immunity, and mood.
• Prebiotic Fiber: To feed beneficial gut bacteria, Asprey formulated InnerFuel Prebiotic, which contains acacia gum, larch arabinogalactan, and guar fiber. He mixes a scoop into his coffee or smoothie daily to promote gut lining health and short-chain fatty acid production, which helps reduce inflammation. He emphasizes that prebiotics have a longer-lasting effect on gut health than probiotics alone.
• Betaine HCl: To aid digestion, Asprey takes 1–2 capsules of betaine HCl with pepsin at the start of larger meals. He found this particularly useful for improving stomach acid levels, which helps break down protein and absorb essential nutrients like B12 and iron. He credits this supplement with preventing bloating and indigestion, especially when eating heavier meals.
• Digestive Enzymes: Asprey uses digestive enzymes to help break down proteins, fats, and carbohydrates. He has taken brands like NOW Super Enzymes and MassZymes to maximize nutrient absorption. When consuming harder-to-digest foods like steak, he pairs digestive enzymes with betaine HCl to support smoother digestion.
• Activated Charcoal: As a defense against food toxins and bloating, Asprey regularly takes activated charcoal capsules, particularly when eating out. He uses 1,000 mg of coconut-shell activated charcoal to bind potential toxins and reduce digestive discomfort. While it won’t prevent alcohol’s cognitive effects, he finds it helpful in minimizing food-related reactions and inflammation.
• Gut Healing Nutrients: Asprey supports gut lining health with collagen and L-glutamine. He highlights that collagen peptides help repair the intestinal lining, especially in cases of inflammation. He also includes bone broth, gelatin, marshmallow root, and aloe vera in his diet to soothe and strengthen gut tissue.
• Anti-Candida and GI Cleanup: To combat gut imbalances, Asprey occasionally takes caprylic acid, berberine, oregano oil, or grapefruit seed extract. He also uses bentonite clay and activated charcoal to detoxify the gut when necessary. These supplements are part of his gut detox protocols aimed at keeping harmful microbes under control.
• Homebiotic & Mold Control: Asprey takes an environmental approach to gut health by minimizing mold exposure in his home. He uses Homebiotic spray, a probiotic-based product designed to reduce mold growth, as he believes mold toxins can negatively impact digestion and immune function.

Asprey’s gut health routine reflects his belief that digestion impacts everything from immunity to mental clarity. By combining probiotics, prebiotics, enzymes, and detoxifiers, he aims to maintain a strong gut microbiome and ensure optimal nutrient absorption.

I usually take a capsule of betaine HCl with meals to increase my stomach acid for better digestion.
Dave Asprey

Sleep Enhancement & Recovery

Dave Asprey views high-quality sleep as one of the most important factors for longevity and daily performance. He focuses on optimizing his body’s ability to relax, regulate hormones, and enter deep sleep stages efficiently. His supplement routine is designed to calm the nervous system, support melatonin production, and improve overall sleep quality without relying on heavy sedatives.

• Magnesium (Various Forms): Asprey considers magnesium essential for both relaxation and overall health. He takes around 600–800 mg daily in different forms, such as glycinate, malate, and threonate. At night, he prefers magnesium glycinate or citrate to relax muscles and promote deeper sleep. In the morning, he takes other forms like malate or orotate for energy support. He often recommends Natural Calm (magnesium citrate) or Magnesium L-Threonate for their brain-boosting benefits.
• “Sleep Mode” (Melatonin + L-Ornithine): To regulate his sleep-wake cycle without high doses of melatonin, Asprey formulated Sleep Mode, which contains 0.3 mg of melatonin, L-ornithine, and herbal extracts. He takes two softgels at bedtime, noting that this low-dose melatonin helps nudge his circadian rhythm without causing grogginess the next day. L-ornithine helps lower cortisol levels, making it easier to unwind before sleep.
• Herbal Tranquilizers (Kava): Asprey occasionally drinks kava tea or takes kava extract in the evenings to relax. He describes kava as a strong herbal sedative that increases GABA activity in the brain, helping reduce stress and tension. He prefers Yogi Kava Stress Relief tea or kava extract capsules, sometimes pairing them with a teaspoon of Brain Octane Oil for better absorption.
• Phenibut (GABA Analog): When struggling with extreme stress or jet lag, Asprey has used phenibut, a synthetic form of GABA that crosses the blood-brain barrier. He follows strict guidelines, taking only 250 mg no more than 1–2 times per week and cycling off completely for extended periods to avoid dependency. He warns that phenibut should never be mixed with alcohol due to its potent effects on GABA receptors.
• 5-HTP: Asprey takes 5-HTP to support serotonin production, which converts into melatonin at night. He typically takes 50–100 mg in the evening to enhance mood and promote restful sleep. He also mentions that 5-HTP can be used throughout the day in small doses to help with stress resilience.
• L-Theanine: Known for promoting relaxation without sedation, L-theanine is a key part of Asprey’s routine. He usually takes 200 mg in the daytime to smooth out caffeine’s effects but sometimes uses it in the evening if he feels wired. It helps lower stress while allowing for a calm, clear-headed state before sleep.
• Glycine: Asprey sometimes takes 3 grams of glycine at night to improve sleep quality and regulate body temperature. He often gets glycine naturally from collagen, which he consumes before bed in drinks like hot chocolate or bone broth. This amino acid supports deeper sleep by relaxing the nervous system.
• Truedark Glasses & Sleep Hygiene: While not a supplement, Asprey wears TrueDark red-lens glasses in the evening to block blue light and support natural melatonin production. He also optimizes his sleep environment by using a cooling mattress, blackout curtains, and temperature regulation tools like chiliPAD or Eight Sleep.
• Miscellaneous Sleep Aids: Asprey occasionally experiments with tryptophan, phosphatidylserine (to lower nighttime cortisol), and herbal blends like valerian, chamomile, and lemon balm. He has also used CBD tinctures for relaxation but emphasizes the importance of sourcing high-quality, toxin-free products.

Asprey’s sleep supplement stack reflects his philosophy of optimizing rest without relying on excessive doses or sedatives. By supporting neurotransmitter function, reducing stress hormones, and maintaining proper sleep hygiene, he aims to improve deep sleep quality and overall recovery efficiency.

I take as many different forms as I can get. I’ve got eight different forms [of magnesium].
Dave Asprey

Stress Resilience & Mood Support

Dave Asprey prioritizes stress management and emotional balance as essential components of peak performance. His supplement regimen includes adaptogens, amino acids, and neurotransmitter precursors that help him stay focused, reduce cortisol levels, and maintain a positive mood. By supporting brain chemistry and nervous system regulation, these supplements contribute to his ability to handle pressure while staying mentally sharp.

• Ashwagandha: This adaptogenic herb helps reduce cortisol levels and increase stress resilience. Asprey takes 500–1000 mg of a high-potency extract like KSM-66 or Sensoril in the morning to promote relaxation and prevent burnout. He considers ashwagandha a daily staple, especially during intense work periods or travel.
• L-Theanine: A natural amino acid found in tea, L-theanine helps create a sense of calm without sedation. Asprey takes 200 mg in the morning with his coffee to smooth out caffeine’s stimulating effects. On stressful days, he may take an additional 200 mg in the afternoon to stay relaxed and improve focus.
• Omega-3 (EPA/DHA): Omega-3 fatty acids from krill oil play a role in brain function and mood regulation. Asprey takes 1–2 grams daily, ensuring a higher EPA-to-DHA ratio for its mood-supporting effects. He finds that adequate omega-3 intake helps keep his mind clear and his mood stable.
• 5-HTP: This serotonin precursor helps support emotional well-being and relaxation. Asprey recommends 50 mg taken multiple times per day, up to six times daily, to maintain balanced serotonin levels. He particularly relies on 5-HTP during winter months or when adjusting to new time zones.
• Mucuna Pruriens (Velvet Bean): A natural source of L-DOPA, mucuna pruriens supports dopamine production, which influences motivation and mood. Asprey takes 100–200 mg of mucuna extract to maintain optimal dopamine levels, especially after periods of prolonged stress.
• Magnesium: Beyond its sleep benefits, magnesium is critical for mood regulation and stress reduction. Asprey supplements with 400–600 mg daily in various forms, ensuring he gets enough to support serotonin production and nervous system function.
• Adaptogenic Herbs: Asprey includes additional adaptogens in his routine for their stress-protective effects:
  • Astragalus: He takes 500 mg to support immune function and protect mitochondria from stress-related damage.
  • He Shou Wu (Fo-Ti): Occasionally used for its brain and liver benefits, Asprey takes 560 mg of this traditional Chinese herb to maintain cognitive resilience.
  • Gynostemma (Jiaogulan): This herb may enhance alpha brain wave activity, promoting a meditative state. Asprey takes 250 mg as a tea or capsule with a fat source for better absorption.
• Kava: Asprey uses kava extract as a natural anxiolytic, comparing its effects to pharmaceutical anti-anxiety medications without sedation. He drinks kava tea or takes a capsule in the morning or before stressful events to promote relaxation while maintaining mental clarity.
• “Happy” Brain Chemicals: To support neurotransmitter production, Asprey occasionally supplements with DL-Phenylalanine or L-Phenylalanine for dopamine and endorphin production. He also takes methylated forms of vitamin B6 and B12 to aid neurotransmitter synthesis.
• Mood Super-nutrients: Asprey has experimented with additional nutrients like inositol (vitamin B8) for anxiety and lithium orotate (5 mg) for mood stabilization. While not daily essentials, he considers them useful tools for specific situations.
• Social and Environmental Factors: Beyond supplements, Asprey emphasizes meditation, controlled breathing, and gratitude practices to enhance resilience. He also uses a soundproof relaxation space at home to further reduce stress levels.

Asprey’s supplement stack for stress and mood is designed to keep cortisol levels in check, optimize neurotransmitters, and promote emotional stability. By combining adaptogens, targeted nutrients, and mindfulness practices, he ensures that stress doesn’t interfere with performance or overall well-being.

Hormones, Fitness & Sexual Health

Dave Asprey takes a proactive approach to maintaining hormonal balance, physical performance, and sexual health. His supplement regimen includes natural compounds that support testosterone levels, muscle preservation, and overall vitality. By combining amino acids, adaptogens, and targeted nutrients, he aims to optimize energy, endurance, and long-term hormonal function.

• Maca Root: Asprey uses gelatinized maca powder, taking 3–5 grams daily for its libido-enhancing and hormone-supporting properties. He adds it to smoothies or coffee, citing its benefits for both men and women. He emphasizes the importance of high-quality sourcing to avoid contamination with mold.
• Tribulus Terrestris: Known for its potential to enhance libido and circulation, Tribulus terrestris is part of Asprey’s routine when needed. He takes 1,000 mg of Tribulus extract, typically in the morning or before sexual activity. While it doesn’t directly raise testosterone, it may support androgen receptor function.
• Zinc & Other Male Health Nutrients: Asprey ensures proper testosterone support with 15–30 mg of zinc, balancing it with copper to avoid deficiencies. He also includes selenium, either through Brazil nuts or a 200 mcg supplement, to aid thyroid and reproductive health.
• Vitamin D & K2: Asprey takes 5,000 IU of vitamin D3 daily, which plays a critical role in testosterone production and metabolic health. He pairs it with vitamin K2 in his ADK supplement to ensure proper calcium utilization.
• Creatine & Aminos for Muscle: To maintain muscle strength, Asprey supplements with creatine monohydrate. He also includes branched-chain amino acids (BCAAs) or essential amino acids (EAAs) around workouts while ensuring he doesn’t overconsume them to preserve autophagy benefits during fasting.
• Carnitine & L-Arginine: Acetyl-L-carnitine (ALCAR) aids fat metabolism and energy production, while also supporting sperm motility. Asprey may also use L-arginine or citrulline for their nitric oxide-boosting effects, which enhance circulation and performance.
• Hormone Replacement Adjuncts: While Asprey has used testosterone replacement therapy (TRT), he also takes supplements like DIM (Diindolylmethane) and calcium D-glucarate to regulate estrogen metabolism. He includes cruciferous vegetables in his diet to further support hormonal balance.
• Bone & Joint Support: Asprey maintains joint health with collagen and omega-3s, which help reduce inflammation. He may also use glucosamine and chondroitin for cartilage support, along with systemic enzymes like serrapeptase to aid recovery.
• Unique Performance Hacks: Asprey has experimented with various performance enhancers, including CB-HD (a cannabinoid) for pre-workout, Cordyceps mushroom for endurance, and caffeine with yohimbine for fasted cardio. He continuously evaluates new supplements while sticking to core strategies that support long-term vitality.

Asprey’s supplement stack for hormones, fitness, and sexual health focuses on maintaining youthful energy, optimizing physical performance, and ensuring long-term well-being. By using natural compounds and essential nutrients, he supports his body’s ability to stay strong, resilient, and hormonally balanced.

You get the right supplements in the right [body], magic happens.
Dave Asprey